
U.Va.'s $350M Manning Institute opens next year with half its space shelled for future fit-out, as data center demand and cost pressures force a phased approach to biotech research infrastructure.
The University of Virginia is building a $350 million biotechnology institute that will open next year with only about half of its 354,000 square feet finished. The rest stays shelled for future fit-out as research priorities shift and funding constraints bite.
The Paul and Diane Manning Institute of Biotechnology, backed by health care entrepreneur Paul Manning's donation plus university and state money, is rising at a school-owned research park in Charlottesville. Five stories tall, it is designed to house cellular and gene therapy labs, nanotechnology research and drug manufacturing under one roof.
U.Va. project director Mashal Hartman said the initial smaller concept grew during predesign. Virginia's exploding data center sector, which soaked up MEP trade workers and drove post-pandemic cost escalation, forced hard choices.
"We felt we had this one shot to make it a dense and different facility," Hartman said. "The decision was made to build out a larger building and fit out as much as we could depending on costs, yet still get research underway as quickly as possible."
Construction manager-at-risk Skanska broke ground in October 2023 after more than a year of planning with lead designer Elkus Manfredi Architects. Early release of several packages let Skanska lock in design-assist subcontractors for the MEP scope, which totals more than $120 million. The building's 2-kilowatt generator has a two-year lead time; custom air handlers take nearly a year.
"From the electrical perspective, we were talking to firms as far away as Boston, Florida and Atlanta to make sure we had the competition and right-size trade partners needed for this project," said Skanska project executive Matt Kidwell.
The university used its state sales tax exemption to buy major system components, lab casework and equipment directly, saving what Hartman called "a tremendous amount of money."
Site preparation, bid 19 months ahead of final design, included relocating one of Charlottesville's primary raw water mains and building a 30-foot-tall retaining wall to extend the site horizontally by 35 feet. The L-shaped building footprint covers about 62,000 square feet.
Subsurface rock proved harder than expected. Initial borings were too sporadic to model the underground profile accurately, Kidwell said. Drilling additional borings at 50-foot intervals on a grid pushed the rock estimate from 8,000 cubic yards to 30,000 – more than half of a 50,000-cubic-yard mass excavation.
The need for blasting was a sensitive issue given the proximity of buildings housing medical services and active research. Hartman said the team held several town hall meetings, some drawing more than 1,000 participants.
Two tower cranes serve the site, including a compact 40-ton-capacity machine positioned at the corner of the building's L to install five 50-foot-long, 22,000-pound floor infill beams. Those beams meet the core lab's stringent vibration criteria and support the primary custom air handling unit.
Vertical construction has been relatively smooth. Structural steel topped off in October 2025 after incorporating nearly 13,300 cubic yards of concrete and more than 3,700 tons of steel. Prefabricated system components sourced from assembly centers as far away as New York and Florida have been critical for MEP-intensive interior work: 717,583 pounds of ductwork and more than 96 miles of electrical conduit.
A year-long BIM coordination effort proved essential for layering systems in the 9 feet of interstitial space above the medicinal chemistry lab, which houses 35 fume hoods. Weekly pull planning keeps installation on track, fitting everything while maintaining an 11-foot ceiling, Kidwell said.
Routing utilities through interior concrete masonry unit walls is just as demanding. Using BIM and other software, Skanska modeled all in-wall utilities to ensure alignment, spacing and ADA compliance before applying a multipart epoxy finish. "Having to move something like a thermostat at that point would be like cutting open a sheetrock wall in an office," Kidwell said.
Most of the two lower floors are being readied for Day 1 operation, including a universal wet lab, a special medicinal chemistry lab and a vivarium. Only portions of the three upper levels are being fit out with universal lab and office space; the rest is shelled. Hartman said locating support areas in the middle of each wing's lab space will maximize long-term flexibility.
"While not tailored to one type of specific research, the layout gives all researchers the ability to share resources," she said. "This allows the building to be very dense."
Future fit-out will include current good manufacturing practice clean rooms for Phase 1 pharmaceutical production, enabling drug companies to work alongside researchers. A café and conference center for all research park tenants are also planned. If demand grows, space is available for a second building. Skanska has already built a 19,000-square-foot thermal energy plant, underground utility distribution and stormwater upgrades to support immediate and long-term needs.
Upcoming milestones include dry-in, completion of the unitized curtain wall and vapor barriers, and energizing sections with permanent power. HVAC installation will be followed by system testing and pressure balancing before researchers move in next year.
Donald Sundgren, U.Va. vice president and chief facilities officer, said the project has already taught lessons about procuring skilled trade services. "Rather than regretting what we did, we want to be glad of what we did," he said, "even if we had to spend a little more."
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