
India produces 50% of the world's medicines but captures only 6% of revenue. With just 10 new drugs in a decade, the sector faces an innovation crisis. Here's what needs to change.
India's pharmaceutical industry makes half the world's medicines by volume. It captures just 6% of global revenue. Over the last decade, only 10 of the 5,000-plus drugs launched worldwide came from Indian labs.
That gap between production and innovation is the central risk for the sector. The next phase – Pharma 5.0, as some call it – requires shifting from manufacturing existing drugs to inventing new ones. China already accounts for a third of global new molecule licensing. India's R&D spending sits at 8% of revenue, well below the Western average of 15%.
Two authors – Lupin's managing director and the writer of 'Made in India' – lay out five areas that need to change. Regulation, universities, capital, collaboration, and procurement. Each one is a bottleneck.
Regulation is the first. China broke ahead by redesigning its drug approval pathways. India's process takes nearly a year. The authors argue for a system that is predictable, ethical, risk-based, and fast. Speed does not mean recklessness, they write. Delays do not guarantee safety.
Universities come next. Nobel Laureate Julius Axelrod's government-funded research on neurotransmitters led to the development of SSRIs. Professor Judith Wurtman at MIT linked them to pre-menstrual disorders, which led to patents, licensing, and eventually a blockbuster drug. India needs technology-transfer offices, a bias toward licensing, shared facilities, and a thicker skin for policymakers dealing with outspoken academics.
Capital – both finance and talent – is the third vector. Drug discovery is like portfolio finance. You underwrite uncertainty. Indian pharma firms must raise R&D spending from 8% to 12%. That means partnerships with venture capital, philanthropy, private equity, and the government. It also means bringing back the scientific diaspora and hiring experienced global talent.
Collaboration is the fourth. Discovery is a team sport. No single company does chemistry, biology, clinical development, regulation, data science, manufacturing, and commercialization equally well. The sector must work with policymakers, universities, startups, global firms, and even Japan and China.
Procurement is the fifth. Innovation policy should aim to create early markets, not just fund labs. Stanford was called the Cold War University because public funding for defence research came with clear government purchase prospects. Indian innovators need predictable public procurement, reimbursement, and inclusion in treatment guidelines.
For investors tracking Indian pharma stocks, this is a key risk to watch. See our stock market analysis for more on sector trends. Companies that raise R&D intensity and build global research centres could capture the upside. Those that stay in generics may see margins compress as competition intensifies.
The authors close with a line that sums up the stakes: "India cannot ask scientists to pursue discoveries and then make it impossible to adopt these for healthcare." The next decade will test whether the sector can move from making medicines to imagining them.
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