Eikon CEO Roger Perlmutter and MD Anderson's Timothy Yap discussed the company's PARP1 selective inhibitors and Werner helicase pipeline, focusing on the potential for improved safety.
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Eikon Therapeutics (EIKN) held a discussion with Cantor Fitzgerald on Thursday, outlining its strategy for next-generation PARP inhibitors and a Werner helicase program.
Chairman and CEO Roger Perlmutter was joined by Dr. Timothy Yap of MD Anderson, a key opinion leader in synthetic lethality. The call, hosted by analyst Imogen Mansfield, covered PARP1 biology, the unmet needs left by first-generation PARP inhibitors, and Eikon's pipeline.
Yap said he has been involved in the development of many first-generation PARP inhibitors and now the new generation PARP1 selective agents. The first-generation drugs block both PARP1 and PARP2, which can cause bone marrow toxicity. Eikon's PARP1 selective inhibitors are designed to avoid that toxicity while maintaining anti-tumor activity.
The call did not include new clinical data. Yap is involved in several Eikon trials but did not share any nonpublic information, Mansfield noted.
Eikon is also advancing a Werner helicase program, targeting another synthetic lethality mechanism in cancers with microsatellite instability. The company has not disclosed specific timelines for data readouts.
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