
CDC ends hantavirus response on MV Hondius cruise ship. All 18 exposed Americans completed quarantine, none tested positive. Three died. Andes strain's human-to-human transmission raises future cruise risk.
The U.S. Centers for Disease Control and Prevention said Wednesday it has officially ended its response to a hantavirus outbreak tied to the MV Hondius cruise ship. All 18 Americans exposed to the virus completed a 42-day quarantine at the Nebraska Medicine Regional Emerging Special Pathogen Treatment Center in Omaha. None tested positive. Another 19 Americans who had left the ship before the outbreak became known were monitored at home, the CDC said.
The Oceanwide Expeditions vessel set sail from Argentina on April 1 with 175 passengers and crew from 23 countries. Twelve cases were confirmed, one suspected. Three people died.
CDC officials credited the quarantine protocol with preventing further spread. The outbreak involved the Andes strain of hantavirus, which can pass between humans. Most hantavirus strains spread only from animals to people. The six-week incubation period meant a long monitoring window was necessary.
“These passengers were navigating uncertainty, disruption to their daily lives, and concerns for themselves and their families,” said Brendan Jackson, acting director of the CDC’s Division of High Consequence Pathogens and Pathology. “I’d like to thank them for their cooperation and commitment to protecting others.”
The closure of the response removes a lingering public health risk tied to the cruise industry. Cruise ships have faced scrutiny over infectious disease outbreaks since the COVID-19 pandemic. The CDC’s ability to isolate exposed passengers and monitor them off the ship shows a containment model that works for rare pathogens. The Andes strain’s human-to-human transmission makes it a higher concern for future outbreaks on vessels where close quarters and shared air systems amplify spread.
No further cases have emerged since the quarantine ended. The CDC said it will continue to work with international health authorities on surveillance for hantavirus in travel settings.
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